MK Dons hand a start to Peter Pawlett for their League One meeting with Fleetwood Town.
The other players bought in to the starting line-up from the FA Cup victory over Hyde United last weekend are Scott Golbourne and Gboly Ariyibi.
Dropping out from that side are Callum Brittain, who is away on international duty, and the benched Aidan Nesbitt and Ryan Seager.
Four players maintain their starting 11 spots from the midweek Checkatrade Trophy win at Oxford. They are George Williams, Ethan Ebanks-Landell, Ariyibi and Ed Upson.
Having won back to back outings in both FA Cup and Checkatrade Trophy, the Dons enter this contest looking for a first league win since late September.
The Dons and Fleetwood won one game each of their two meetings last season, with both sides winning the respective away encounter. MK Dons were 4-1 winners at Highbury, while Fleetwood were 1-0 victors at stadium:mk in the reverse fixture.
MK Dons starting 11: Nicholls, Williams, Wootton, Ebanks-Landell, Golbourne, Pawlett, Upson, Gilbey, Ariyibi, Aneke, Agard
Substitutes bench: Sietsma, Lewington, Walsh, McGrandles, Nesbitt, Thomas-Asante, Seager