MK Dons suffered a second defeat in as many games at the start of the season as they lost 1-0 to Sheffield Wednesday.
A Josh Windass penalty put the visitors in front midway through the first half.
Despite losing Will Grigg and Nathan Holland to injury, MK Dons did have a decent number of chances to equalise in the second period, but were unable to find a breakthrough as they slipped to a reverse.
The result is back-to-back defeats at the start of the new season in League One.
After defeat away at Cambridge in their opening match of the new League 1 season, the Dons entered their home opener seeking a first win and goal of the 2022/23 campaign.
They would be in for a tricky test, however, in the form of Sheffield Wednesday, who beat the Dons in a crucial match near the end of the previous season, even if Darren Moore’s team arrived with availability issues up front.
Liam Manning’s team featured first starts for Dan Oyegoke, Bradley Johnson and Louie Barry, as well as first home starts for Jack Tucker and Nathan Holland, and a second debut for former loan recruit Ethan Robson.
It was the visitors who had some bright openings in the early moments of the contest, though the best chance fell for Barry Bannan as the away captain saw a strike charged down by Dean Lewington.
Will Vaulks would later see two attempts on goal blocked, but the away side did start with some bright running.
As the half wore on, MK Dons did begin to see more of the ball, with Louie Barry on the right flank attempting to lead a few charges.
Brentford loanee Dan Oyegoke saw a drive flash wide, before Will Grigg saw an effort of his own blocked by David Stockdale and then ricochet across goal and away.
This lead to a fairly even spell of football as both teams tried to find themselves a way through, with the single best chance seeing Matt Smith have a try charged down.
But just after the 20 minute mark, the visitors struck first. MK Dons were unable to clear their lines, and a foul by Dean Lewington on Windass was given by the referee.
From 12 yards, Windass duly beat Jamie Cumming to give the visitors the game’s opening goal.
The visitors lost defender Akin Famewo just after the goal, with the game seeing a smattering of some chances as Nathan Holland had a strike blocked before Fisayo Dele-Bashiru blasted one into the stands.
MK Dons then suffered a blow as Will Grigg was taken off injured, with the returning striker pulling up while chasing a loose ball.
Bradley Johnson saw an ambitious try bounce wide, before Wednesday came close to a second in six minutes of stoppage time, as Dele-Bashiru robbed Oyegoke before having a shot saved by Cumming, and Ben Heneghan headed wide at the resulting corner.
Jack Hunt saw a drive deflected wide just after the break, before the Dons suffered another injury problem as Holland had to be taken off.
The Dons began to offer a bit more as the second half carried on. After a few dangerous crosses, they had a few chances in quick succession as Stockdale denied Matt Smith and then also denied Dean Lewington’s follow-up, before Matt Dennis just couldn’t force the rebound past the goal-side of the post.
Barry would see a shot from range kept out by Stockdale, but the away goalkeeper that frustrated the Dons in last season’s play-offs would intervene again, making a firm save to deny Dons sub Dan Kemp in a one-on-one.
Sheffield Wednesday withdrew both Bannan and Windass, with the Dons introducing home debutants Conor Grant and Darragh Burns in their attempts to find an equaliser.
But the Dons would be unable to create much, with Wednesday having a few late half-chances during eight minutes of stoppage time but otherwise able to round out the clock.
MK Dons: Cumming – Oyegoke, O’Hora, Tucker, Lewington – Johnson, Robson (Grant 79) – Barry (Burns 79), Smith, Holland (Kemp 53) – Grigg (Dennis 41)
Subs not used: Ravizzoli, Lawrence, Jules
Sheffield Wednesday: Stockdale – Ihiekwe, Heneghan, Famewo (Hunt 29) – Palmer, Dele-Bashiru, Vaulks, Bannan (Byers 77), Johnson – Windass (Bakinson 77), Paterson
Subs not used: Dawson, Iorfa, James, Sow
Goal: Windass (pen 22)
Booked: Ihiekwe, Bannan